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PharmGKB (Pharmacogenetics and Pharmacogenomics Knowledge Base) (Whirl-Carrillo et al., 2021): A comprehensive resource that curates knowledge about the impact of genetic variation on drug response for clinicians and researchers

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however, aggregates of TTR, including oligomeric forms, have previously been linked to cytotoxicity [81,82,83,84,85] supporting the possibility that misfolded TTR may contribute to this response

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Understanding your genetic predispositions helps your PlexusDx provider anticipate whether you'll respond robustly at 5 mg or need to climb toward 15 mg, personalizing your titration schedule and maintenance target before you even begin